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. 2019 Feb 27;19:10. doi: 10.1186/s40644-019-0189-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Patient with partial response. a) Post-contrast T1-weighted turbo-FLASH. Source image shows the region of interest (ROI) drawn around the tumor, AATH-calculated k_ep parametric map (1/min) from b) pre-treatment c) intra-treatment and d) post-treatment study are shown. Tumor reduced in size which was flowed by a reduction in the k_ep during the course of chemotherapy. The distribution of the k_ep is spatially heterogenous with high values in the periphery and low values in the core