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. 2019 Feb 20;10:91. doi: 10.3389/fgene.2019.00091

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Copyright © 2019 Yue, Li, Liu, Wu, Li, Lei, Huang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The main frame of data processing. (1) High-throughput sequencing data were pre-selected according to the | log₂FC| ≥ 4(| log₂FC| ≥ 2 for DEMs) and P-values < 0.001. (2) The DEMis-DEMs pairs were obtained using LncACTdb. (3) According to MFE theory, the DEMis-DELs pairs were screened using the RNAhybrid program. (4) the DEMis-DEMs pairs were merged with the DEMis-DELs pairs to obtain the co-expression RNAs. (5) 46 co-expression lncRNAs, 17 co-expression miRNAs, and 79 co-expression mRNAs were finally selected to construct the lncRNA–miRNA–mRNA network. DELs, differentially expressed lncRNAs; DEMis, differentially expressed miRNAs; DEMs, differentially expressed mRNAs; MFE, minimum free energy.