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. Author manuscript; available in PMC: 2019 Feb 27.
Published in final edited form as: Endocrine. 2016 Sep 23;54(3):768–777. doi: 10.1007/s12020-016-1083-6

Fig. 3.

Fig. 3

Correlations between intronic DNA methylation levels in Intron 2 Region 2 CpG-3 and hippocampal volumes in CS patients and controls. a Correlation between the left hippocampal volume (LHV) and DNA methylation at Intron 2 Regions 2 CpG-3 for CS patients and controls. There was a significant correlation between LHV and Intron 2 Region 2 CpG-3 (r = 0.73, p = 0.02) in active CS patients. b Correlation between the right hippocampal volume (RHV) and DNA methylation at Intron 2 Regions 2 CpG-3 for all Cushing’s and Control samples are shown. A weaker but still significant correlation was observed in active Cushing’s patients (r = 0.58, p = 0.03). X-axis: % of DNA methylation, Y-axis: hippocampal volumes, mm3.