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. Author manuscript; available in PMC: 2019 Jun 12.
Published in final edited form as: Nature. 2018 Dec 12;565(7739):318–323. doi: 10.1038/s41586-018-0804-9

Figure 3. Conformational differences between gp120-bound and other liganded CCR5s.

Figure 3.

(a) The section of the CCR5 CRS2 (divided into a major and a minor subpocket) is shown in surface representation for the [5P7]CCL5, gp120 and maraviroc complexes, respectively. Interacting residues, including Pro3 from [5P7]CCL5, Pro311 from the V3 loop, and compound maraviroc, are in stick model. (b) Superposition of the structures of the gp120-CCR5 complex (red) and the maraviroc-CCR5 complex (blue). N-terminus, ELC2 and seven TM helices (I, II, III, IV, V, VI, VII) are indicated. (c) Superposition of the structures of the gp120-CCR5 complex (red) and the [5P7]CCL5-CCR5 complex (blue).