Figure 7.

Basal subtype of breast cancer is linked with high IL1β and anakinra-dependent signature. A, IL1B transcript expression in different breast cancer subtypes annotated in the METABRIC database. N, number of samples per subtype. Kruskal–Wallis test was P < 0.001. B, The gene sets controlled by anakinra treatment in the blood were used in unsupervised analyses of transcriptional datasets from invasive BrCa tumors in the METABRIC datasets. Two clusters were formed on the basis of gene expression and assigned as red and black clusters. C, IL1B transcription in two clusters in both datasets. D, Number of patients in each cluster among different subtypes of breast tumors.