Table 1.

Key regulatory sites and sequences on KCC2.

Site	Localization	References
Protein Associated with Myc (PAM)	1069-1088	Garbarini and Delpire (2008)
LVLLNMPGPPRNRNGDENYM
PEST sequence	PEST-1: 949-966	Mercado et al. (2006)
	PEST-2: 974-1002
ISO domain	1021-1035	Mercado et al. (2006)
PSPVSSEGIKDFFSM
AP-2 interaction domain	657-662	Zhao et al. (2008)
LLRLEE
SPAK-OSR1 interaction domain
RFTV	4–7	Piechotta et al. (2002)
Cysteines	287-302-322-331	Hartmann et al. (2010)
N-Glycosylation sites	283-291-310-328-338-339	Agez et al. (2017)
Tyrosines	34-787-906-1007	Rinehart et al. (2009), de Los Heros et al. (2014), Weber et al. (2014) and Cordshagen et al. (2018)
	34, 999, 1009
	34, 1009
Serines	728-940-1,034	Lee et al. (2007), Weber et al. (2014) and Cordshagen et al. (2018)
	31, 913, 932, 988
	25, 26, 937, 1022, 1025, 1026

Positions are shown relative to the human KCC2b protein.