Table 3.
Differentially expressed lncRNAs between Lapatinib high_IC50 and low_IC50 groups of 420 cancer cell lines (fold-change >1.5, P < 0.01).
| Probes | Title | Symbol | Ensemble transcript id version | Log FC | P-value | Adj. P-value |
|---|---|---|---|---|---|---|
| 225381_at | mir-100-let-7a-2 cluster host gene (non-protein coding) | MIR100HG | ENSG00000255248.7 | 1.339024 | 4.98E-08 | 1.48E-05 |
| 226546_at | uncharacterized LOC100506844 | GIHCG | ENSG00000257698.1 | 1.19665 | 1.52E-15 | 8.13E-12 |
| 228564_at | Long intergenic non-protein coding RNA 1116 | LINC01116 | ENSG00000163364.9 | 1.122804 | 4.24E-06 | 0.000493 |
| 227554_at | MAGI2 antisense RNA 3 | MAGI2-AS3 | ENSG00000234456.7 | 1.096172 | 2.73E-07 | 5.84E-05 |
| 1566482_at | NA | RP11-305O6.3 | ENSG00000250280.2 | 0.961776 | 3.96E-08 | 1.24E-05 |
| 213156_at | Zinc finger and BTB domain containing 20 | ZBTB20 | ENSG00000259976.3 | 0.942404 | 6.68E-06 | 0.000649 |
| 213158_at | Zinc finger and BTB domain containing 20 | ZBTB20 | ENSG00000259976.3 | 0.908785 | 1.6E-05 | 0.001179 |
| 244741_s_at | ZNF667 antisense RNA 1 (head to head) | ZNF667-AS1 | ENSG00000166770.10 | 0.873077 | 0.000703 | 0.019471 |
| 229480_at | MAGI2 antisense RNA 3 | MAGI2-AS3 | ENSG00000234456.7 | 0.870971 | 4.07E-07 | 8.05E-05 |
| 229493_at | HOXD cluster antisense RNA 2 | HOXD-AS2 | ENSG00000237380.6 | 0.795366 | 2.89E-07 | 5.94E-05 |
| 227082_at | Zinc finger and BTB domain containing 20 | ZBTB20 | ENSG00000259976.3 | 0.780225 | 5.64E-05 | 0.003174 |
| 226587_at | Prader Willi/Angelman region RNA 6 | PWAR6 | ENSG00000257151.1 | 0.777959 | 0.0002 | 0.008638 |
| 242358_at | RASSF8 antisense RNA 1 | RASSF8-AS1 | ENSG00000246695.7 | 0.770905 | 9.02E-08 | 2.29E-05 |
| 236075_s_at | Uncharacterized LOC101928000 | LOC101928000 | ENSG00000234327.7 | 0.766575 | 6.6E-06 | 0.000649 |
| 221974_at | Imprinted in Prader-Willi syndrome (non-protein coding) /// uncharacterized LOC101930404 /// Prader Willi/Angelman region RNA, SNRPN neighbor /// small nucleolar RNA, C/D box 107 /// small nucleolar RNA, C/D box 115–13 /// small nucleolar RNA, C/D box 115–26 /// small nucleolar RNA, C/D box 115–7 /// small nucleolar RNA, C/D box 116–22 /// small nucleolar RNA, C/D box 116–28 /// small nucleolar RNA, C/D box 116–4 /// small nuclear ribonucleoprotein polypeptide N |
IPW /// LOC101930404 /// PWARSN /// SNORD107 /// SNORD115-13 /// SNORD115-26 /// SNORD115-7 /// SNORD116-22 /// SNORD116-28 /// SNORD116-4 /// SNRPN |
ENSG00000224078.13 | 0.719911 | 0.000535 | 0.016616 |
| 227099_s_at | Chromosome 11 open reading frame 96 | C11orf96 | ENSG00000254409.2 | 0.686826 | 0.001963 | 0.037596 |
| 217520_x_at | Uncharacterized LOC101929232 /// PDCD6IP pseudogene 2 |
PDCD6IPP2 | ENSG00000274253.4 | 0.671638 | 1.03E-05 | 0.000862 |
| 226591_at | Prader Willi/Angelman region RNA 6 | PWAR6 | ENSG00000257151.1 | 0.665136 | 0.000597 | 0.018108 |
| 233562_at | Long intergenic non-protein coding RNA 839 | LINC00839 | ENSG00000185904.11 | 0.644287 | 0.000226 | 0.009558 |
| 228370_at | Imprinted in Prader-Willi syndrome (non-protein coding) /// uncharacterized LOC101930404 /// Prader Willi/Angelman region RNA, SNRPN neighbor /// small nucleolar RNA, C/D box 107 /// small nucleolar RNA, C/D box 115–13 /// small nucleolar RNA, C/D box 115–26 /// small nucleolar RNA, C/D box 115–7 /// small nucleolar RNA, C/D box 116–22 /// small nucleolar RNA, C/D box 116–28 /// small nucleolar RNA, C/D box 116–4 |
IPW /// LOC101930404 /// PWARSN /// SNORD107 /// SNORD115-13 /// SNORD115-26 /// SNORD115-7 /// SNORD116-22 /// SNORD116-28 /// SNORD116-4 |
ENSG00000224078.13 | 0.63548 | 0.004004 | 0.056605 |
| 230272_at | Long intergenic non-protein coding RNA 461 /// microRNA 9-2 |
LINC00461 /// MIR9-2 |
ENSG00000245526.10 | 0.633241 | 0.000333 | 0.011874 |
| 227121_at | Zinc finger and BTB domain containing 20 | ZBTB20 | ENSG00000259976.3 | 0.622039 | 6.47E-05 | 0.003438 |
| 228438_at | Uncharacterized LOC100132891 | LOC100132891 | ENSG00000235531.9 | 0.610992 | 0.00111 | 0.026335 |
| 213447_at | Imprinted in Prader-Willi syndrome (non-protein coding) /// uncharacterized LOC101930404 /// Prader Willi/Angelman region RNA, SNRPN neighbor /// small nucleolar RNA, C/D box 107 /// small nucleolar RNA, C/D box 115–13 /// small nucleolar RNA, C/D box 115–26 /// small nucleolar RNA, C/D box 115–7 /// small nucleolar RNA, C/D box 116–22 /// small nucleolar RNA, C/D box 116–28 /// small nucleolar RNA, C/D box 116–4 /// small nuclear ribonucleoprotein polypeptide N |
IPW /// LOC101930404 /// PWARSN /// SNORD107 /// SNORD115-13 /// SNORD115-26 /// SNORD115-7 /// SNORD116-22 /// SNORD116-28 /// SNORD116-4 /// SNRPN |
ENSG00000224078.13 | 0.603999 | 0.000792 | 0.021388 |
| 238632_at | NA | RP11-44F21.5 | ENSG00000260265.1 | −0.58771 | 0.000615 | 0.018108 |
| 224646_x_at | H19, imprinted maternally expressed transcript (non-protein coding) /// microRNA 675 |
H19 /// MIR675 |
ENSG00000130600.18 | −0.66521 | 0.008633 | 0.089285 |
| 243729_at | NA | RP11-747H7.3 | ENSG00000260711.2 | −0.68534 | 2.63E-09 | 1.08E-06 |
| 1557779_at | Uncharacterized LOC101928687 | LOC101928687 | ENSG00000231131.6 | −0.69525 | 0.000133 | 0.006282 |
| 229296_at | Uncharacterized LOC100506119 | LOC100506119 | ENSG00000233901.5 | −0.74915 | 3.12E-05 | 0.001938 |
| 1557094_at | Uncharacterized LOC100996760 | LOC100996760 | ENSG00000276850.4 | −0.80357 | 4.07E-05 | 0.002362 |
| 223779_at | AFAP1 antisense RNA 1 | AFAP1-AS1 | ENSG00000272620.1 | −0.80513 | 6.36E-05 | 0.003434 |
| 235921_at | Uncharacterized LOC102723721 | LOC102723721 | ENSG00000223784.1 | −0.81799 | 9.33E-06 | 0.000804 |
| 1558216_at | AFAP1 antisense RNA 1 | AFAP1-AS1 | ENSG00000272620.1 | −0.84595 | 0.000286 | 0.010641 |
| 242874_at | NA | RP11-747H7.3 | ENSG00000260711.2 | −0.92003 | 9.63E-11 | 6.43E-08 |
| 227985_at | Uncharacterized LOC100506098 | LOC100506098 | ENSG00000233834.6 | −1.04243 | 7.5E-08 | 2E-05 |
| 236279_at | NA | NA | ENSG00000275234.1 | −1.04592 | 6.12E-10 | 2.97E-07 |
| 232202_at | Family with sequence similarity 83, member B | FAM83B | ENSG00000261116.1 | −1.07231 | 2.29E-10 | 1.22E-07 |
| 238742_x_at | Uncharacterized LOC102724362 | SPINT1-AS1 | ENSG00000261183.5 | −1.10252 | 6.38E-14 | 1.7E-10 |
| 226755_at | MIR205 host gene (non-protein coding) | MIR205HG | ENSG00000230937.11 | −1.11922 | 1.11E-10 | 6.61E-08 |
| 242354_at | NA | RP11-532F12.5 | ENSG00000261183.5 | −1.19239 | 5.99E-13 | 8.01E-10 |
| 229223_at | NA | RP11-96D1.11 | ENSG00000262160.1 | −1.26926 | 1.78E-12 | 1.59E-09 |
| 201510_at | E74-like factor 3 (ets domain transcription factor, epithelial-specific) | ELF3 | ENSG00000249007.1 | −1.54591 | 1.36E-13 | 2.42E-10 |
| 210827_s_at | E74-like factor 3 (ets domain transcription factor, epithelial-specific) | ELF3 | ENSG00000249007.1 | −1.63868 | 8.23E-13 | 8.79E-10 |
| 227919_at | Urothelial cancer associated 1 (non-protein coding) | UCA1 | ENSG00000214049.7 | −1.65999 | 9.68E-08 | 2.35E-05 |
log FC, log2 of fold-change. Positive value indicates increased expression in high_IC50 group, and negative value indicates decreased expression in high_IC50 group. NA, Not available.