FIG 2.

Analogs of RN18 inhibit replication in nonpermissive cells, but not in permissive cells. Nonpermissive H9 (a to c) or permissive MT4 (d to f) T-cell lines were treated overnight with various micromolar concentrations of each analogue before infection with equivalent amounts of HIV-1LAI. Cells were maintained 8 to 12 days in the presence or absence of inhibitors, and viral replication was monitored every other day by reverse transcriptase activity in culture supernatants. Data are representative of results from at least three independent experiments.