FIG 5.

In silico model of IMC15 bound to Vif in complex with the E3 ligase and A3G. IMC15 is rendered in stick form, with surface density represented in gray (a). Vif is rendered as a dark blue ribbon, with EloB in orange, EloC in light green, CBF-β in light blue, Cullin 5 in red, and A3G in dark green. IMC15 binds Vif in proximity to the APOBEC binding region, destabilizing Vif-APOBEC interactions. IMC15 makes primary stabilizing Van der Waals interactions with V142 and π-cation interactions with Arg 167 (b). IMC15 is rendered in stick form, with surface density shown in gray. Vif is rendered as a dark blue ribbon, with CBF-β as a light blue ribbon.