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. 2019 Feb 20;10:71. doi: 10.3389/fpsyt.2019.00071

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Copyright © 2019 Jyonouchi, Geng, Rose, Bennuri and Frye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–D) Changes in mitochondrial respiration (PLR, ALR, MRC, and RC) in ASD subjects studied at 2–3 time points, showing that in some ASD subjects revealed stable these parameters, while others show fluctuating these parameters. Five ASD subjects (4 males and 1 female) showed stable clinical conditions without fluctuating behavioral symptoms, while 8 ASD subjects (7 males and 1 female) revealed fluctuating behavioral symptoms (anxiety, irritability, OCD, and self-injurious behaviors) along with fluctuating GI (diarrhea alternating with constipation) symptoms.