Table 7.
Associations between parameters of mitochondrial respiration (PLR, ALR, and MRC) and IL-1ß/IL-10 ratios by PBMo under various culture conditions.
| IL-1ß/IL-10 ratio correlation with PLR, ALR, and MRCa | IL-1ß/IL-10 ratiod based ASD subgroups | Non-ASD control cells (N = 38) | ||
|---|---|---|---|---|
| High ratio (N = 56) | Normal ratio (N = 59) | Low ratio (N = 22) | ||
| PLRc | No association | No association | No association | No association |
| ALR | ||||
| Ratio (medium) | −0.4379 (p < 0.001)b | −0.0752 | 0.0594 | 0.1133 |
| Ratio (LPS) | −0.3638 (p < 0.01) | 0.3294 (p < 0.02) | 0.117 | 0.1882 |
| MRCe | ||||
| Ratio (medium) | −0.3275 (p < 0.02) | 0.0676 | 0.0407 | 0.0783 |
| Ratio (LPS) | −0.1612 | 0.4935 (p < 0.0001) | 0.2333 (p < 0.005) | −0.1055 |
| Ratio (CL097) | −0.0323 | −0.1066 | −0.5885 (p < 0.005) | −0.264 |
a
Values of Correlation coefficients revealed significant results in at least one of ASD subgroups or non-ASD controls are shown. Stimulants used for cultures of PBMo are shown in the parentheses.
b
Correlation coefficient by Spearman test. Statistically significant values are shown with p-values.
c
Abbreviations used: please see Table 3
d
Definition of high, normal, and low ratio groups are detailed in the method section.
e
Correlations between RC and IL-1ß/IL-10 ratios are almost identical as observed in associations between MRC and ratios. Thus, not shown in the table.