Figure 10.

SK1 expression induces a metabolic switch known as the Warburg effect in A2780 ovarian cancer cells.23 From the comparison between A2780 mock (blue) and SK1‐expressing cells (red) emerges that expression of SK1 induced a high glycolytic rate (a), characterized by increased levels of lactate, and decreased oxidative metabolism, associated with the accumulation of intermediates of the TCA (b). Changes in metabolite levels caused by SK1 overexpression were statistically significant by paired Wilcoxon test, *P‐value<0.05.