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Activation level during the critical contrast (lures called “similar” minus lures called “old”) based on hybrid anatomical/functional ROIs, for both the initial presentation (encoding) and subsequent presentations (retrieval) based on APOE ε4 carrier status. During both encoding and retrieval, the APOE ε4+ risk group showed increased hippocampal activity bilaterally in the CA1 (A, B) and, in the left DG/CA3 (C).
