Figure 1.

Photoresponsive HA hydrogel nanocomposite with photo-controlled 3-D ECM adhesion sites for dynamic macrophage immunomodulation. Schematics of (A) photoresponsive HA hydrogel nanocomposites generated with HA-Ac macromers and alkoxylphenacyl-based polycarbonate (APP) nanocarrier (purple) loaded with RGD peptide (yellow), and (B), upon defined UV exposure, RGD peptides will covalently conjugate (blue “Y”) onto crosslinked HA hydrogels (white) to temporally activate αvβ3 integrin macrophage expressions for macrophage polarization in a dynamic 3-D HA ECM composite.