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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Curr Opin Hematol. 2019 Jan;26(1):6–15. doi: 10.1097/MOH.0000000000000472

Figure 2. Examples of extensive neutrophil profiles in BTHS patients.

Figure 2.

(A and B) UPN37 and 80 respectively did not satisfy mathematical criteria for cycling. (A) UPN37 appeared to cycle at an average of 25 days (range 23–28 days). His G-CSF response is shown in Figure 4A. (B) UPN48 showed spontaneous variability between an ANC of zero and 5.3 × 109/L over a period of 61 days; Unpredictable variation in this manner is the most common pattern seen in BTHS patients. (C and D) Two patients (UPN35 & 36 respectively) exhibited periods of rhythmic “microcycling” over periods averaging 8–9 days either around (in C) or above (in D) the threshold of neutropenia.