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. Author manuscript; available in PMC: 2019 Feb 27.
Published in final edited form as: Cell Rep. 2019 Jan 22;26(4):1010–1020.e5. doi: 10.1016/j.celrep.2018.12.105

Figure 5. Ex Vivo Optical Low-Frequency Stimulation Induces LTD Only at Potentiated MGN-LA Synapses.

Figure 5.

(A) Scatterplots demonstrating the effect of ex vivo optical LTD induction on EPSP rise slope at MGN-LA terminals. 15 min of 1-Hz optical stimulation induced a sustained reduction in EPSP rise slope only in cocaine-trained non-CS-re-exposed animals.

(B) Quantification of (A), demonstrating the effect of 1-Hz stimulation on EPSP rise slope as a percent change from baseline. LTD induction significantly decreased the EPSP rise slope relative to baseline only in cocaine-trained non-CS re-exposed animals (paired t test, t(6) = 3.34, *p = 0.016). Inset, sample average EPSP traces across groups during baseline (Pre, black) and 1 h after LTD induction (Post, red); scale bars, 100 ms, 10 mV; error bars, mean SEM; n in bars = number of neurons. See also Figure S5.