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. Author manuscript; available in PMC: 2020 Mar 15.
Published in final edited form as: Eur J Med Chem. 2019 Jan 31;166:339–350. doi: 10.1016/j.ejmech.2019.01.080

Figure 1.

Figure 1.

eIF4E biological activity and structure. (A) Structure of the m7GpppX cap. (B) Crystal structure of eIF4E bound to the m7GpppX cap (PDB: 1EJ1). The key tryptophan residues for cap binding are highlighted, in addition to lysines close to the cap-binding pocket.