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. Author manuscript; available in PMC: 2020 Mar 15.
Published in final edited form as: Eur J Med Chem. 2019 Jan 31;166:339–350. doi: 10.1016/j.ejmech.2019.01.080

Figure 5.

Figure 5.

Western blot analysis of eIF4E following the m7GDP cap competition assay in HEK293 cell lysate. (A) Immobilized eIF4E was treated with 500 μM of m7GDP or a GDP- or Bn7GDP-based PROTAC. DMSO was used as a negative control. (B) Dose-dependent inhibition by 23a.