FIG. 5:

C(VI)-transformed human lung bronchial cells (BEP2D cells) grow tumors in Nude mice. Passage-matched control BEP2D cells and Cr(VI)-transformed BEP2D cells (BPD-CrT cells) were injected subcutaneously into the flanks of 6-week-old athymic Nude mice (1 × 10⁶ cells per mouse) and checked weekly for tumor appearance. There were eight subcutaneous injection sites per cell line. (A) Tumor incidences. (B) Tumor volume measured after euthanasia. Tumor volume was determined by calipers following the formula A × B² × 0.52, where A is the longest diameter of tumor and B is the shortest diameter. (C) Tumor weights. Data are expressed as the mean ± SEM.