Fig. 1.

Reduced promoter occupancy is a major form of Pol II dysregulation in metabolic gene promoters under PO conditions. ChIP-seq was performed with anti-Pol II antibody after 4 days of TAC. The Pol II occupancies in known or predicted PPAR (A) and ERR (B) target gene promoters were shown. Open arrows indicate direction of gene body, and therefore, origin of the arrow indicates promoter region, whereas arrow head indicates transcription termination site. Blue arrows indicate at least 15% reduction of a peak of Pol II occupancy in the promoter region under PO conditions. X-axis is length of genomic region (Kbp). Y-axis is relative ChIP coverage provided by Integrated Genome Browser.