Table 1.

Echocardiographic data of PGC-1α-cKO mice under PO conditions.

	Cre BL(6)	Cre PO(6)	Wild BL(17)	Wild PO(17)	cKO BL(9)	cKO PO(7)	cKO-AAV-con(5)	cKO-AAV-PGC-1α(6)
HR, bpm	429±79	440±36	456±60	495±52	438±47	389±38§	466±32	436±61
LVEDD, mm	3.19±0.34	3.74±0.53	3.27±0.44	3.96±0.43†	4.25±0.47†	4.55±0.49‡	4.41±0.46	3.82±0.29||
LVESD, mm	2.09±0.41	2.92±0.68	2.13±0.43	3.03±0.54†	3.18±0.39†	4.15±0.36§	3.37±0.59	2.37±0.34#
LVEF, %	72.0±9.1	52.0±14.9	71.8±8.8	54.9±13.1†	57.6±7.5†	23.3±7.0§	54.9±12.8	76.0±5.6#
LVFS, %	34.9±7.1	22.5±8.2	35.1±6.7	24.0±7.7†	25.1±4.4†	8.5±2.8§	23.9±7.2	38.2±4.7#
DSEP WT, mm	0.71±0.12	0.91±0.06	0.83±0.13	0.93±0.14	0.80±0.15	0.77±0.17‡	0.77±0.04	0.81±0.20
DP WT, mm	0.77±0.22	0.77±0.10	0.88±0.17	0.89±0.13	0.68±0.09*	0.64±0.12§	0.73±0.12	0.85±0.11||
SSEP WT, mm	0.99±0.19	1.06±0.16	1.14±0.28	1.17±0.26	1.00±0.23	0.83±0.17§	0.92±0.07	1.18±0.16#
SP WT, mm	0.90±0.29	0.86±0.13	1.01±0.17	1.10±0.16	0.89±0.13	0.72±0.26§	0.95±0.21	1.18±0.20 ||
Age Month	2.52±0.88	4.17±0.60	3.82±0.47	3.09±0.97	3.82±0.77	2.68±0.81	3.11±0.77	2.80±0.74

HR, heart rate; LV, left ventricle; EDD, end-diastolic dimension; ESD, end-systolic dimension; EF, ejection fraction, FS, fractional shortening; DSEP, Diastolic septal; DP, Diastolic posterior; SP, Systolic posterior; SSEP, systolic septal; WT, wall thickness.

Data are mean ± SD.

^*p<0.01;

^†p<0.01vs Wild BL

^‡p<0.05;

^§p<0.001 vs Wild PO

^||p<0.05;

^#p<0.01vs cKO-AAV Cont.

Parenthesis indicates N.