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. 2018 Jul 16;11(2):144–157. doi: 10.1093/jmcb/mjy038

Figure 7.

Figure 7

Self-signaling of IL-6RA at intracellular compartments limits IL-6 synthesis by dendritic cells. Model scheme depicting the interplay of synthesis, trafficking, and intracellular signaling of IL-6. LPS binding to TLR4 promotes the transcription of IL-6 and SOCS3. SOCS3 is rapidly degraded by the proteasome. Newly synthesized IL-6 in transit to the plasma membrane self-signals from endosomal compartments prior to secretion. Extracellular IL-6 is taken up by the cell and also signals from endosomal compartments. This leads to an increased pY-STAT3 activation (phosphorylation of Tyr705), which represses the transcription of IL-6. pY-STAT3 activation, in turn, is inhibited by the increased level of SOCS3. ER, endoplasmic reticulum.