Table 2. Results of univariate and multivariate analyzes of the effect of the number of recurrences on progression-free survival—variable time-dependent cox model.

		BOTH PROGRESSION FREE TIME *		PROGRESSION TO HIGH GRADE Ta / T1 FREE TIME
		HR (CI 95%)		HR (CI 95%)
		Univariate	Multivariate ƚ	Univariate	Multivariate ƚ
Number of recurrences	1	1.50 (0.72–3.11)	0.92 (0.41–2.06)	2.04 (0.88–4.75)	0.90 (0.33–2.46)
	2–3	1.47 (0.64–3.39)	0.90 (0.36–2.23)	2.66 (1.07–6.61)	1.51 (0.54–4.10)
	> = 4	0.95 (0.31–2.90)	0.51 (0.15–1.69)	0.91 (0.18–4.52)	0.43 (0.07–2.53)

* Both type of progression: NMIBC or MIBC.

Univariate and multivariate hazard ratios were estimated using variable time-dependant cox model.

ƚ Adjusted on age, sex, smoking, previous treatment and stratified on the EORTC risk score (low versus moderate/high) at baseline.