Table 2. Univariate Cox regression analysis of KLK4 mRNA expression levels and patients’ survival in advanced high-grade ovarian cancer (FIGO III/IV).
Clinical parameters | OS | PFS | ||||
---|---|---|---|---|---|---|
No a | HR (95% CI) b | p | No a | HR (95% CI) b | p | |
Age | 0.348 | 0.627 | ||||
≤ 60 years | 50 | 1 | 43 | 1 | ||
> 60 years | 76 | 1.27 (0.77–2.08) | 65 | 1.12 (0.70–1.79) | ||
Residual tumor mass | < 0.001 | < 0.001 | ||||
0 mm | 64 | 1 | 59 | 1 | ||
> 0 mm | 60 | 3.76(2.18–6.48) | 49 | 2.53 (1.60–4.02) | ||
Ascites fluid volume | 0.011 | 0.018 | ||||
≤ 500 ml | 72 | 1 | 63 | 1 | ||
> 500 ml | 47 | 1.93 (1.16–3.18) | 39 | 1.78 (1.10–2.87) | ||
KLK4 mRNA c | 0.001 | 0.121 | ||||
low | 62 | 1 | 55 | 1 | ||
high | 63 | 2.28(1.38–3.76) | 52 | 1.44(0.91–2.78) |
Significant p-values (p < 0.05) are indicated in bold.
a Number of patients; due to missing values, numbers do not always add up to n = 126 (OS) and n = 108 (PFS).
b HR: hazard ratio (CI: confidence interval) of univariate Cox regression analysis.
c Dichotomized into low and high levels by median.