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. 2019 Feb 27;14(2):e0212968. doi: 10.1371/journal.pone.0212968

Table 2. Univariate Cox regression analysis of KLK4 mRNA expression levels and patients’ survival in advanced high-grade ovarian cancer (FIGO III/IV).

Clinical parameters OS PFS
No a HR (95% CI) b p No a HR (95% CI) b p
Age 0.348 0.627
≤ 60 years 50 1 43 1
> 60 years 76 1.27 (0.77–2.08) 65 1.12 (0.70–1.79)
Residual tumor mass < 0.001 < 0.001
0 mm 64 1 59 1
> 0 mm 60 3.76(2.18–6.48) 49 2.53 (1.60–4.02)
Ascites fluid volume 0.011 0.018
≤ 500 ml 72 1 63 1
> 500 ml 47 1.93 (1.16–3.18) 39 1.78 (1.10–2.87)
KLK4 mRNA c 0.001 0.121
low 62 1 55 1
high 63 2.28(1.38–3.76) 52 1.44(0.91–2.78)

Significant p-values (p < 0.05) are indicated in bold.

a Number of patients; due to missing values, numbers do not always add up to n = 126 (OS) and n = 108 (PFS).

b HR: hazard ratio (CI: confidence interval) of univariate Cox regression analysis.

c Dichotomized into low and high levels by median.