Table 2. Sketch of significant inflammatory/profibrogenic mediators in p28 Reeler vitreous.
Mediator | Function | FC (Sign) | Cell origin in the retina | [ref] |
---|---|---|---|---|
βNGF | Growth factor | 7.23 (*) | all cells | [1,2,50] |
IL33 | Pro-inflammatory and pro-fibrogenic cytokine | 4.96 (*) | glial cells | [35,40] |
TIMP1 | Metalloproteinase inhibitor | 4.79 (*) | glial cells | [52] |
Values obtained from protein chip array showing the fold changes (FC) in the expression of some inflammatory/profibrogenic mediators at p28 Reeler retina as compared to WT. Significant values (Sign) are labeled by asterisk (*, p<0.05) or ns (not significant).