Fig 6. Kidney matrix-metalloproteinase (MMP) up-regulation and nitric oxide (NO) generation during L. obliqua envenomation: Effects of aprotinin treatment.
Kidneys from Wistar rats pre-treated or not with aprotinin were collected after 24h of L. obliqua venom injection and MMP-9 (A) and MMP-2 (B) activities were measured by gelatin zymography. C. Kidney NO levels were estimated by the Griess method. Data represents mean ± SE. * denotes p<0.05 vs PBS group and # denotes p<0.05 vs group treated with LOBE.