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. 2018 Nov 13;8(3):301–312. doi: 10.1002/sctm.18-0056

Figure 5.

Figure 5

Ex vivo stimulation of MSCs with serum yielded further reduction of lung remodeling in vivo. Collagen fiber content in (A) lung parenchyma and (B) airway. Representative photomicrographs of lung parenchyma (original magnification: ×200) and airways (original magnification: ×400) stained by the Picrosirius‐polarization method (C). CTRL, phosphate‐buffered saline‐challenged mice; HDM, HDM‐challenged mice; SAL, HDM mice treated with saline; MSC, HDM mice treated with unstimulated MSCs; HDM‐MSC‐BALF, HDM mice treated with MSCs stimulated with BALF from asthmatic mice; HDM‐MSC‐SERUM, HDM mice treated with MSCs stimulated with serum from asthmatic mice. Boxes show the interquartile (P25–P75) range, whiskers denote the range (minimum–maximum), and horizontal lines represent the median of eight animals per group. Scale bars: 100 μm. *, Significantly different from CTRL (p < .05). **, Significantly different from HDM‐SAL (p < .05). Abbreviations: BALF, bronchoalveolar lavage fluid; MSC, mesenchymal stromal cells; HDM, house dust mite.