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. 2018 Nov 13;8(3):301–312. doi: 10.1002/sctm.18-0056

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© 2018 The Authors stem cells translational medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Ex vivo stimulation of MSCs with serum led to further improvement in lung mechanics in vivo. Static lung elastance (Est,L; upper panel), resistive (ΔP1,L), and viscoelastic (ΔP2,L) pressures (lower panel). CTRL, phosphate‐buffered saline‐challenged mice; HDM, HDM‐challenged mice; SAL, HDM mice treated with saline; MSC, HDM mice treated with unstimulated MSCs; HDM‐MSC‐BALF, HDM mice treated with MSCs stimulated with BALF from asthmatic mice; HDM‐MSC‐SERUM, HDM mice treated with MSCs stimulated with serum from asthmatic mice. Bars represent mean ± SD of eight animals per group. *, Significantly different from CTRL (p < .05). **, Significantly different from HDM‐SAL (p < .05). ^#, Significantly different from HDM‐MSC (p < .05). Abbreviations: BALF, bronchoalveolar lavage fluid; MSC, mesenchymal stromal cells; HDM, house dust mite.