Table 1.
Ureaplasma parvum Infection and Inflammation
| Variable | Control (n = 8) |
U. parvum
Infecteda |
|
|---|---|---|---|
| 3 d (n = 5) | 7 d (n = 5) | ||
| Fetal weight, mean (SD) g | 331 (7.2) | 348 (44) | 341 (18) |
| Gestational age at delivery, mean (SD), d | 132 (0.8) | 132 (4.3) | 131 (1.2) |
| Histologic chorioamnionitis, No. | 1/8 | 0/5 | 1/5 |
| U. parvum quantitative culture, median (IQR), CFUs × 103/mL | |||
| Fetal membrane | 0 | 0 (0–0.2) | 0.2 (0–0.9) |
| Amniotic fluid | 0 | 0.1 (0.03–84) | 3900 (1875–9275) |
| U. parvum detection by PCR, No. | |||
| Fetal membrane | 0/8 | 4/5 | 4/5 |
| Amniotic fluidb | 0/5 | 5/5 | 5/5 |
| Maternal uterus | ND | 0/5 | 3/5 |
| Fetal lung | ND | 4/5 | 5/5 |
| Fetal spleen | ND | 0/5 | 2/5 |
| Fetal thalamus | ND | 1/5 | 0/5 |
Abbreviations: CFUs, colony-forming units; IQR, interquartile range; ND, not determined; PCR, polymerase chain reaction; SD, standard deviation; U. parvum, Ureaplasma parvum.
aU. parvum (1 × 107 CFUs) was given via intra-amniotic injection.
b Data from only 5 of 8 control animals.