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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Clin Exp Allergy. 2018 Nov 29;49(3):317–330. doi: 10.1111/cea.13301

Figure 6. Administration of sub-therapeutic levels of anti-IL-13 and IL-17A significantly improve lung function and limit neutrophil recruitment in HDM-treated A/J mice.

Figure 6.

Asthma was induced as in Materials and Methods. Anti-IL-17A (75 μg/injection), anti-IL-13 (4 μg/injection), anti-IL-17A + anti IL-13, or Rat IgG2a (79 μg/injection) was administered i.p. 48 hours before, and 48 hours after each HDM exposure. (A) methacholine-induced AHR was measured by Flexivent. BALF was collected, and the number of macrophages (B), eosinophils (C), neutrophils (D), and lymphocytes (E) were assessed. Data are mean ± SEM of n = 10 – 12 mice from 2 independent experiments. ***p < 0.001 and ****p < 0.0001 versus PBS. † < 0.05 versus isotype.