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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Clin Exp Allergy. 2018 Nov 29;49(3):317–330. doi: 10.1111/cea.13301

Figure 7. Simultaneous blockade of IL-13 and IL-17A at sub-therapeutic individual doses significantly reduces IL-13-induced gene expression, without impacting expression of IL-17A-induced genes.

Figure 7.

(A) Lung cells were restimulated in vitro with HDM and IL-5, IL-10, IL-13, and IL-17A production was evaluated by ELISA. (B) Pulmonary expression of IL-13-driven genes (Alox15, Arg1, Tff2) and (C) IL-17A-induced genes (Cebpb, Cebpd, Bd2) was assessed by RT-PCR analysis. Data are mean ± SEM of n = 10 – 12 mice from 2 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, and **** p < 0.0001 versus PBS. † < 0.05 and †† < 0.01 versus isotype.