Table 4:

Temporal Trends in Cause-Specific Risk of Death in ESRD due to Lupus Nephritis (1995–2014)

Year of ESRD Initiation	N	Number of Deaths	Unadjusted HR (95% CI)	Age-, Sex-, BMI-Adjusted HR (95% CI)	Multivariate† Adjusted HR (95% CI)
Cardiovascular Disease
1995–1999	4,861	475	1.00 (ref)	1.00 (ref)	1.00 (ref)
2000–2004	5,413	501	0.95 (0.83–1.08)	0.96 (0.84–1.09)	1.01 (0.88–1.17)
2005–2009	5,540	414	0.76 (0.66–0.87)	0.77 (0.68–0.89)	0.82 (0.71–0.95)
2010–2014	5,160	279	0.53 (0.45–0.61)	0.53 (0.45–0.61)	0.56 (0.48–0.67)
P-for-trend			<0.001	<0.001	<0.001
Infection
1995–1999	4,861	218	1.00 (ref)	1.00 (ref)	1.00 (ref)
2000–2004	5,413	227	0.91 (0.75–1.10)	0.91 (0.75–1.11)	0.91 (0.74–1.12)
2005–2009	5,540	152	0.57 (0.46–0.70)	0.58 (0.47–0.72)	0.58 (0.46–0.72)
2010–2014	5,160	91	0.37 (0.29–0.47)	0.37 (0.29–0.47)	0.37 (0.28–0.48)
P-for-trend			0.001	<0.001	<0.001
Other
1995–1999	4,861	378	1.00 (ref)	1.00 (ref)	1.00 (ref)
2000–2004	5,413	458	1.05 (0.92–1.21)	1.07 (0.93–1.23)	1.15 (0.99–1.34)
2005–2009	5,540	474	1.05 (0.91–1.20)	1.09 (0.94–1.25)	1.16 (1.00–1.35)
2010–2014	5,160	390	0.91 (0.79–1.06)	0.92 (0.80–1.07)	1.01 (0.86–1.18)
P-for-trend			NS	NS	NS

^†Adjusted for age, sex, BMI, diabetes, hypertension, current smoker, coronary artery disease, congestive heart failure, cerebrovascular accident, region, and first modality