Figure 8.

Crosslinking modulation of biodegradation and host cell recruitment. Collagen and collagen-Ph solutions were subcutaneously injected into nude mice and polymerized to form collagen (left) and collagen-Ph (right) hydrogels. Constructs were evaluated after 7 days in vivo. (a) Modulation of in vivo degradation profiles on collagen hydrogels and collagen-Ph hydrogels with various amounts of collagen-Ph and G’. Quantification of total murine myeloid cells (b) surrounding host tissue and (c) inside the hydrogel constructs. In collagen hydrogels, P-values less than 0.01 and 0.001 were considered statistically significant and were labeled ## and ### compared with the 0.15% collagen hydrogel. In collagen-Ph hydrogels, P-values less than 0.1, 0.01, 0.001 were considered statistically significant and were labeled *, **, and *** compared with the 0.15% collagen-Ph hydrogel with the same G’. P-values less than 0.1 were considered statistically significant and were labeled # compared with the collagen-Ph hydrogel with G’ of 50 Pa at the same concentration.