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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Mol Neurobiol. 2018 Aug 27;56(5):3576–3590. doi: 10.1007/s12035-018-1325-0

Figure 6.

Figure 6.

Cocaine-mediated ER stress-dysregulated autophagy mediated inflammation involves σ−1Rin HBVP. Representative western blots showing the protein levels of BiP (A), ATF 6 (B), IRE 1α (C), p-PERK/ PERK (D), p-EIF/ EIF (E), BECN1 (F), LC3B-II (G) and p62 (H) in HBVP pretreated with 10 μM BD 1047 for 1 h followed by 10 μM cocaine exposure for 12h. (I) RT-qPCR showing relative expression of proinflammatory cytokines such as TNF-α, IL 1β and IL 6 mRNA in HBVP pretreated with 10 μM BD 1047 for 1 h followed by 10 μM cocaine exposure for 6 h. Data are presented as mean ± SEM; the mean is derived from 6 independent experiments (n = 6). Abbreviation: Coc: Cocaine. One-way ANOVA followed by Bonferroni post hoc test was used to determine the statistical significance: *, P<0.05 vs. control; #, P<0.05 vs. cocaine.