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. 2019 Jan 30;176(6):773–786. doi: 10.1111/bph.14562

Figure 5.

Figure 5

Effect of class I and II kinase on the activity of RyR2 single channels. (A) Representative 3 s continuous segments of channel currents recorded at +40 mV. The first column shows recordings before the application of each kinase inhibitor, and the second column shows the same channel following the application of each kinase inhibitor (10 μM CX‐4945, ponatinib, nilotinib or 1 μM sunitinib) to the cytosolic side of the channel. P o values shown were calculated over a full 30 s recording. (B) P o (mean ± SEM) for channels before and after the addition of each kinase inhibitor. n = 6, 6, 5 and 5 independent channels/experiments for CX‐4945, sunitinib, ponatinib and nilotinib respectively.