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. 2018 Dec 4;47(4):2011–2028. doi: 10.1093/nar/gky1209

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — FMHM inhibits HCC by suppressing the RPS3/SIRT1 pathway. (A) CHX chase assay was performed in HepG2 cells treated with or without FMHM. Cellular proteins were extracted for Western blotting analysis. (B) Quantitation of CHX chase assay was done by densitometry and expressed as signals of RPS3/GAPDH. (C) FMHM reduces SIRT1 mRNA half-life. (D–G) FMHM down-regulates the mRNA and protein levels of RPS3/SIRT1 and up-regulates the mRNA and protein levels of PPARγ in a dose-dependent manner. *P < 0.05, **P < 0.01 and ***P < 0.001.