A time trade-off study is a feasible method to elicit patient preferences and value short-term changes in quality of life alongside a clinical trial.

Extensive piloting and revisions are required when developing the time trade-off materials to ensure they are fit for purpose. The involvement of clinicians and patients during this process is essential.

The complex nature of time trade-off interviews is likely to require face-to-face interviews, and together with an extensive development process, it is important that sufficient time and funding is allocated for the process.