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. 2018 Dec 29;47(4):1786–1796. doi: 10.1093/nar/gky1282

Figure 3.

Figure 3.

(A) Distribution of H3K4me3 scores around Pol III genes across time. Dots represent isolated Pol III loci whose H3K4me3 scores are above the cutoff. (B) Distribution of RPB2 scores around Pol III genes across time and replicates. Dots represent isolated Pol III loci whose RPB2 scores are above the cutoff. (C) Scatterplot of RPC4 scores T statistic and H3K4me3 fold change from TP0 to TP36. All Pol III loci are shown (n = 646). (D) Plot of RPB2 scores T statistic estimated for the transition TP0 to TP36 as a function of the RPB2 average score, across replicates, at TP0. RPB2 scores were computed in a region of ±1 kb around Pol III gene TSS. A positive value of the T statistic indicates an increase of score from TP0 to TP36. Red dots and black dots, genes with an associated FDR< and >0.05, respectively; grey dots, genes with RPB2 scores below cut-off. (E) Scatterplot of RPC4 and RPB2 scores T statistic, from TP0 to TP36. All Pol III loci are shown (n = 646). (F) Scatterplot of RPC4 T statistic and fold change of RPB2 occupancy at nearby Pol II TSS (±250 bp of the Pol II TSS). The Pol III loci considered (both isolated and not isolated) had RPC4 scores above the cutoff and were within 2.65 kb of a Pol II TSS with a corresponding RPB2 peak (n = 52).