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Interactions that stabilize the ‘closed’ (A) and ‘open’ (B) states of the S6–S7 turn in WT and V143A mutant forms of p53 DBD respectively. Residue 143 is shown in red sticks. The ‘closed’ state is populated in simulations of the WT DBD while the ‘open’ state is largely populated in the simulations of destabilizing mutants.
