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Characterizing the novel S6–S7 pocket. (A) The final frame of the V143A mutant type DBD is taken as a representative to highlight the S6–S7 pocket. The residues lining the pocket are indicated. (B) Residues used to quantify the pocket are shown in p53 DBD. Two dihedral angles (arrows) and a distance measure (dotted line), shown in the figure on right, are used to define a geometric criteria to characterize the pocket.
