Table 2.
Associations of serum tryptophan and kynurenine concentrations with clinical parameters at the time of admission.
| Women | Men | |||||
|---|---|---|---|---|---|---|
| Trp [μmol/L] | Kyn [μmol/L] | Kyn/Trp [μmol] | Trp [μmol/L] | Kyn [μmol/L] | Kyn/Trp [μmol] | |
| Age [years] |
r = −0.025 p = 0.697 |
r
=
0.298** p = 0.000 |
r
=
0.308** p = 0.000 |
r = −0.131 p = 0.077 |
r
=
0.241** p = 0.001 |
r
=
0.331*** p = 0.000 |
| BMI [kg/m2] |
r = 0.151* p = 0.020 |
r
=
0.238** p = 0.000 |
r = 0.161* p = 0.013 |
r = 0.047 p = 0.526 |
r
=
0.300*** p = 0.000 |
r
=
0.269*** p = 0.000 |
| Smoking severity |
r = 0.078 p = 0.228 |
r = −0.79 p = 0.222 |
r = −0.128 p = 0.048* |
r = −0.009 p = 0.909 |
r = −0.176 p = 0.019* |
r = −0.195 p = 0.009* |
| BDI-II |
r = −0.121 p = 0.064 |
r = −0.123 p = 0.059 |
r = −0.80 p = 0.221 |
r = −0.188* p = 0.012 |
r
= –0.243** p = 0.001 |
r = −0.165* p = 0.028 |
| HAM-D |
r = −0.143* p = 0.035 |
r = −0.081 p = −231 |
r = 0.007 p = 0.920 |
r = −0.145 p = 0.058 |
r = −0.181* p = 0.018 |
r = −0.113 p = 0.140 |
| GSI |
r = −0.159* p = 0.014 |
r = −0.124 p = 0.056 |
r = −0.68 p = 0.298 |
r = −0.116 p = 0.119 |
r = −0.115 p = 0.123 |
r = −0.043 p = 0.567 |
| hsCRP |
r = 0.093 p = 0.148 |
r
=
0.216** p = 0.001 |
r
=
0.189** p = 0.003 |
r = −0.112 p = 0.128 |
r = 0.186* p = 0.012 |
r = 0.229 p = 0.002** |
| IL-6 |
r = −0.024 p = 0.707 |
r = 0.163* p = 0.011 |
r = 0.183 p = 0.004* |
r = −0.150 p = 0.042 |
r = 0.073 p = 0.322 |
r = 0.163* p = 0.027 |
*
significant at p < 0.005;
**
significant if corrected for Bonferroni at p < 0.004; BMI, body mass index; hsCRP, high sensitive reactive protein; IL-6, interleukin 6; BDI-II, Becks Depression Inventory; HAM-D, Hamilton Depression Score; GSI, Global severity index (SCL); Trp, Tryptophan; Kyn, Kynurenine.