Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 21;9:48. doi: 10.3389/fonc.2019.00048

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Loh, Arya, Naema, Wong, Sethi and Looi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

STAT3 siRNA delivery using Polyethyleneimine (PEI), Ploy L-co-glycolic Acid (PLGA), and Inorganic compound, such as gold nanoparticles and Hydroxyapatite (HAP) nanoparticles to target ovarian cancer cells, malfunctioned dendritic cells, lung cancer cells, melanoma cancer cells, and prostate cancer cells. STAT3 siRNA delivery using polypeptides, solid lipid nanoparticles, polysaccharide, and aptamer. Poly (ethylene glycol)-b-poly (L-lysine)-b-poly (L-leucine) (PEG-PPL-PLLeu) is used to target melanoma cells while Triethylamine hybrid nanoparticles (tLypl-hNPs) targets Regulatory T-cells. Legumin-targeting strategy is employed to targeting breast cancer cells using encapsulated hydrocarbon carrier. Anionic charged siRNA co-assembled with polysaccharide hyaluronan-sulfate (HAS) to target mouse colon cancer cells. Gint4.T-STAT3 was developed to deliver STAT3 siRNA to PDGFRβ⁺ Glioblastoma cancer cells. PAMAM Dendrimer was used to deliver EGFR siRNA and miR-150 to suppress STAT5 expression in colon cancer cells and AML cells, respectively. Polypeptide PEGylated-anisamide-LPH nanoparticle was used to transfect lung cancer cells with STAT5B targeting non-apeptide, EV.