Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 27;9:2973. doi: 10.1038/s41598-018-37777-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

P. gingivalis LPS and the TLR2 agonist Pam₂CSK₄ increase the expression of BDKRB1 and BDKRB2 mRNA in human gingival fibroblasts. Time-course of the expression of BDKRB1 and BDKRB2 in human gingival fibroblasts cultured in the presence or absence of 10 μg/mL of P. gingivalis LPS (A,B). P. gingivalis LPS dose dependently increased mRNA expression of BDKRB1 (C) and BDKRB2 (D) in human gingival fibroblasts after 6 h of treatment with LPS. Pam₂CSK₄ (50 ng/mL) increased BDKRB1 and BDKRB2 mRNA in human gingival fibroblasts after 6 h of treatment (E). Data were normalized against RPL13A and are expressed as percentage of the means for the controls at 3 h (A) or controls (B–E), which was arbitrarily set to 100%. Values represent means for 3 wells/experimental group and SEM is shown as vertical bar. * and ** indicate significant difference to untreated control cells, P < 0.05 and P < 0.01, respectively. Statistical significance was determined using Student’s t test (A, B and E) or one-way analysis of variance (ANOVA), with Levene’s homogeneity test and Dunnet’s T3 post hoc test (C,D).