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. 2019 Feb 27;9:2973. doi: 10.1038/s41598-018-37777-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The role of IL-1β and TNF-α in P. gingivalis LPS mediated up-regulation of BDKRB1 and BDKRB2 mRNA. Gingival fibroblasts were exposed to 1 μg/mL of LPS from P. gingivalis for 6 h in the presence or absence of anti-IL-1β (0.3 μg/mL) (A,B) or anti-TNF-α (1 μg/mL) (C,D) and the expression of BDKRB1 (A,C) and BDKRB2 (B,D) mRNA was analyzed by qPCR using Taqman Assays. Data were normalized against RPL13A and expressed as percent of control which was arbitrarily set to 100%. Data are expressed as means ± SEM (n = 4 wells/experimental group. *** and *** indicate significant difference, P < 0.05, P < 0.01 and P < 0.001, respectively. Statistical analysis was determined using one-way analysis of variance (ANOVA), with Levene’s homogeneity test and Tukey post hoc test.