Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 27;9:2973. doi: 10.1038/s41598-018-37777-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Proposed role of kinin receptors in gingival fibroblasts for the invasion of P. gingivalis in gingival blood vessels. LPS from P. gingivalis is released from the biofilm on teeth at the inflammatory site and binds to TLR2, composed either by the heterodimer TLR1/TLR2 or TLR6/TLR2 in the cell membrane of human gingival fibroblasts. At the same time, the kinin-releasing protease gingipain expressed by P. gingivalis promotes the generation of kinins at the inflammatory site. Activation of TLR2 leads to the expression of kinin receptor mRNA and protein by gingival fibroblasts. The binding of BK and DALBK to B2 and B1 receptors, respectively, expressed by the fibroblasts leads to the release of PGE₂. Kinins and PGE2 may act as vasodilator agents, facilitating the penetration of bacteria into the blood vessels and their spreading to other tissues.