Table 4.
Serum cytokines and adipokines in CD vs. control subjects.
| Control n = 27 | CD n = 114 | p-value | q-value | |
|---|---|---|---|---|
| GM-CSF (pg/mL) | 3.5 ± 3.2 | 21.3 ± 24.8 | <0.001 | 0.010 |
| Lipocalin-2 (ng/mL) | 287.8 ± 143.6 | 480.2 ± 261.5 | <0.001 | 0.010 |
| CCL11 (pg/mL) | 140.3 ± 86.8 | 246.3 ± 164.4 | <0.001 | 0.010 |
| GRO (pg/mL) | 899.5 ± 428.0 | 1274.2 ± 863.4 | 0.005 | 0.029 |
| VEGF (pg/mL) | 139.8 ± 106.7 | 303.1 ± 258.6 | 0.006 | 0.029 |
| HGF (pg/mL) | 460.8 ± 235.7 | 687.2 ± 427.9 | 0.006 | 0.029 |
| Resistin (ng/mL) | 33.0 ± 12.9 | 45.0 ± 21.2 | 0.005 | 0.029 |
| IL-17A (pg/mL) | 1.8 ± 1.6 | 9.1 ± 15.2 | 0.009 | 0.037 |
| IL-7 (pg/mL) | 2.7 ± 2.9 | 6.4 ± 6.6 | 0.012 | 0.045 |
| G-CSF (pg/mL) | 16.8 ± 19.8 | 36.4 ± 39.4 | 0.020 | 0.067 |
| IFN-γ (pg/mL) | 10.2 ± 10.6 | 35.1 ± 41.1 | 0.023 | 0.070 |
| IL-5 (pg/mL) | 2.4 ± 2.8 | 14.3 ± 22.6 | 0.035 | 0.078 |
| IL-8 (pg/mL) | 8.9 ± 7.9 | 17.0 ± 20.3 | 0.032 | 0.078 |
| IL-9 (pg/mL) | 1.1 ± 0.7 | 4.0 ± 4.1 | 0.035 | 0.078 |
| IL-12p40 (pg/mL) | 25.2 ± 26.0 | 119.1 ± 158.7 | 0.037 | 0.078 |
| Adipsin (ng/mL) | 3016.5 ± 610.4 | 2794.5 ± 1002.0 | 0.029 | 0.078 |
| Adiponectin (ng/mL) | 36290.8 ± 34202.6 | 30218.8 ± 39636.7 | 0.045 | 0.089 |
| MIP-1α (pg/mL) | 12.0 ± 6.6 | 52.4 ± 67.5 | 0.049 | 0.090 |
| MIP-1β (pg/mL) | 20.8 ± 12.7 | 38.9 ± 39.2 | 0.058 | 0.090 |
| IL-15 (pg/mL) | 2.4 ± 1.3 | 8.1 ± 10.4 | 0.057 | 0.090 |
| IL-10 (pg/mL) | 3.2 ± 2.4 | 15.4 ± 21.3 | 0.052 | 0.090 |
| IFNA2 (pg/mL) | 69.3 ± 40.0 | 31.8 ± 30.8 | 0.059 | 0.090 |
| FGF-2 (pg/mL) | 60.3 ± 48.3 | 79.4 ± 52.3 | 0.100 | 0.132 |
| TGF-α (pg/mL) | 10.4 ± 20.1 | 4.8 ± 5.8 | 0.103 | 0.132 |
| IL-1α (pg/mL) | 38.3 ± 49.9 | 110.8 ± 116.1 | 0.108 | 0.132 |
| IL-6 (pg/mL) | 2.3 ± 2.6 | 6.4 ± 7.9 | 0.110 | 0.132 |
| MDC (pg/mL) | 971.2 ± 357.8 | 1131.6 ± 475.7 | 0.110 | 0.132 |
| PAI-1 Total (ng/mL) | 69.2 ± 22.5 | 77.5 ± 25.4 | 0.101 | 0.132 |
| MCP-1 (pg/mL) | 427.4 ± 120.9 | 510.2 ± 254.9 | 0.238 | 0.276 |
| MCP3 (pg/mL) | 120.8 ± 92.3 | 294.4 ± 416.2 | 0.254 | 0.284 |
| IP-10 (pg/mL) | 361.2 ± 124.4 | 373.3 ± 269.4 | 0.274 | 0.297 |
| NGF (pg/mL) | 1.9 ± 1.5 | 4.0 ± 5.9 | 0.292 | 0.307 |
| EGF (pg/mL) | 76.4 ± 45.5 | 93.6 ± 61.4 | 0.311 | 0.317 |
| TNF-α (pg/mL) | 7.6 ± 3.1 | 12.8 ± 25.7 | 0.370 | 0.367 |
| TNF-β (pg/mL) | 65.1 ± 64.5 | 169.1 ± 251.6 | 0.452 | 0.434 |
| SCD40L (pg/mL) | 6088.7 ± 4605.2 | 4923.9 ± 2966.3 | 0.506 | 0.472 |
| IL-13 (pg/mL) | 34.2 ± 30.1 | 93.3 ± 142.1 | 0.617 | 0.559 |
| Leptin (pg/mL) | 19081.1 ± 14513.8 | 18957.0 ± 18409.4 | 0.632 | 0.559 |
| Fractalkine (pg/mL) | 160.6 ± 136.3 | 217.1 ± 289.5 | 0.877 | 0.737 |
| IL-1ra (pg/mL) | 43.3 ± 51.0 | 103.4 ± 231.4 | 0.863 | 0.737 |
Data are shown as mean ± SD. P-values are calculated with a Mann-Whitney U test and q-values by the Benjamini and Hochberg method where 0.05 was considered significant. Two samples were missing cytokine/adipokine measurements.