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. 2019 Feb 27;9:2952. doi: 10.1038/s41598-019-39367-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Thalamo-cortical functional connectivity in schizophrenia and healthy subjects. (A) Six cortical ROI masks were overlaid onto the standard MNI brain. (B) Functional thalamic subdivision was created using the winner-takes-all strategy, in which each thalamic voxel was labelled according to the cortical ROI with the highest connectivity strength. (C) Significantly altered thalamocortical connectivity in schizophrenia patients compared to healthy subjects. The patient group showed decreased PFC-thalamic functional connectivity and increased motor-thalamic and somatosensory-thalamic connectivity. *Indicates p < 0.05 and ***Indicates p < 0.001. Error bars represent standard error.