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. 2019 Feb 27;9:2877. doi: 10.1038/s41598-019-38979-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ranking of features including chromatin regulators and TFs in mESC and pro-B cells. (a) Box plot shows the importance of features, including histone modifications, chromatin regulators, coactivators, DNaseI and other features. The feature importance is calculated by using a Random Forest based algorithm, Boruta. The colors represent (Blue = shadow features; Red = negative features; Orange = Important features; Green = Neutral features). (b) Box plot shows the feature importance for 11 TFs in mESC. (c) Box plot shows the importance of feature after combining the chromatin, coactivators and TFs features in mESC. (d) Box plot shows the importance features, including chromatin, coactivators and master TFs in pro-B cells.