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. 2019 Feb 27;10(3):207. doi: 10.1038/s41419-019-1384-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a A set of 602 mRNAs showed an increase in abundance of log₂FC ≥ 1, while AGAP2-AS1 also reduced the abundance of 1090 genes (log₂FC ≤ −1) in RNA profiles, based on RNA transcriptome sequencing of the control group and the siRNA-AGAP2-AS1 group. b GO analysis showed that the influenced genes could be grouped into six categories on the basis of the KEGG pathway involved: cellular processes, environmental information processing, genetic information processing, human diseases, metabolism, and organismal systems. c Heat map showing the expression change of the most variable 40 genes in BxPC-3 cells after transfection with si-NC and si-AGAP2-AS1. Gene expression is shown as RPKM after log10 conversion. d, e Relative expression levels of ANKRD1 and ANGPTL4 in AsPc-1 and BxPC-3 cells transfected with si-NC or si-AGAP2-AS1 were measured using qRT-PCR. f–h ANKRD1 and ANGPTL4 protein levels were detected by western blot analysis in AsPC-1 and BxPC-3 cells transfected with si-NC and si-AGAP2-AS1. i MTT experiments were performed to determine the cell viability of BxPC-3 cells transfected with si-NC, si-ANKRD1, si-AGAP2-AS1, si-AGAP2-AS1 + si-ANKRD1. *P < 0.05, **P < 0.01, ***P < 0.001