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. 2019 Feb 27;9:2867. doi: 10.1038/s41598-019-39394-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TSA improves the hair follicle-inductive capacity of culture expanded SKPs. (A,B) Hair genesis of SKPs treated with different concentration of TSA. SKPs in P5 were treated with different concentrations of TSA and implanted into excisional wounds in nude mice in combination with freshly isolated neonatal mouse epidermal cells. Twenty-one days post transplantation, hairs generated at the wound sites were photographed (A), and the number of hairs in each wound was counted (B, mean ± SEM; n = 5; *P < 0.05; ** P < 0.01). Scale bars: 1 mm. (C,D) Immunofluorescence staining of tissue sections of the wounds with DAPI and anti-GFP antibody showed that more neogenic hair follicles containing GFP-expressing SKPs were found in wounds receiving TSA-treated SKPs, compared to wounds receiving SKPs without TSA treatment (C). Error Bars represent means ± SEM; n = 5; **P < 0.01; ***P < 0.001. Scale bars: 100 μm.